POLYDIMETHYL SILOXANE

Silicone oil has been used extensively in Europe and investigationally in the United States for the long-term reattachment of complicated retinal detachments. The silicone oil may be used as permanent vitreous replacement or temporarily with an idea of avoiding the long-term complications. Silicone oil can greatly improve success rates in eyes that have failed standard treatment for retinal detachment and advanced proliferative vitreoretinopathy.

Indications

It is indicated in complex retinal detachments, severe diabetic tractional retinal detachments, giants tears and traumatic retinal detachments as a short-term tamponade in the repair of eyes with large, multiple, or posterior breaks, retinal detachments.

Dosage

Dosage of PDMS varies depending on the specific formulation and intended use. It is typically administered orally in the form of tablets or capsules for gastrointestinal issues, or topically in creams and lotions for skincare purposes. Specific dosing instructions should be followed as directed by healthcare providers or product labels.

Contra-Indications

PDMS is generally well-tolerated, but individuals with known hypersensitivity to silicone-based products should avoid its use. It is not recommended for use in patients with severe gastrointestinal conditions without medical supervision.

Special Precautions

Caution should be exercised when using PDMS in patients with a history of allergic reactions. Ingestible forms of PDMS should be taken with sufficient water to ensure proper passage through the digestive system.

Side Effects

Silicone oil can cause cataract and corneal decompensation, glaucoma, pupillary block, keratopathy, iritis and endophthalmitis. Common side-effects associated with PDMS are rare but may include mild gastrointestinal discomfort such as nausea or diarrhea. Allergic reactions are extremely rare but possible.

Drug Interactions

PDMS is not known to interact significantly with other medications when used as directed. However, it is advisable to consult healthcare professionals before combining PDMS with other medications or supplements.