Potassium Clavulanic Acid

Potassium Clavulanic Acid is a beta-lactamase inhibitor that is combined with penicillin group antibiotics to overcome antibiotic resistance in bacteria that secrete beta-lactamase, which would otherwise inactivate the antibiotic.

Indications

Used in combination with penicillin antibiotics to treat various infections including respiratory tract infections, urinary tract infections, skin infections, and sinusitis.

Dosage

-Dosage varies based on the specific antibiotic combination and the severity of the infection. -Commonly prescribed as part of fixed-dose combinations with amoxicillin or other penicillins. -Always follow the dosage instructions provided by the healthcare provider.

Contra-Indications

-Hypersensitivity to clavulanic acid, penicillins, or any component of the formulation. -History of jaundice or hepatic dysfunction associated with the use of clavulanic acid/penicillin combinations.

Special Precautions

-Monitor liver function periodically during prolonged therapy -Use with caution in patients with hepatic impairment or severe renal impairment -Adjust dosage in patients with renal dysfunction -Assess for signs of allergic reactions, especially in patients with a history of penicillin allergy

Side Effects

Gastrointestinal disturbances (nausea, vomiting, diarrhea)

Drug Interactions

-May interact with oral contraceptives, reducing their efficacy -Probenecid can decrease renal excretion of Potassium Clavulanic Acid -May enhance the anticoagulant effect of warfarin -Concurrent use with allopurinol increases the risk of rash