Prucalopride
Prucalopride is a selective serotonin 5-HT4 receptor agonist used primarily as a prokinetic agent to treat chronic constipation. It works by stimulating the serotonin receptors in the gastrointestinal tract, enhancing motility and facilitating bowel movements. It is a selective, high affinity serotonin (5-HT4) receptor agonist with enterokinetic activities. Prucalopride alters colonic motility patterns and stimulates colonic mass movements.Chronic Constipation: Specifically used in adults with chronic constipation who have not responded adequately to other treatments.
-Adults: The usual recommended dose is 2 mg once daily. In some cases, the dose may be adjusted to 1 mg daily depending on individual tolerance and response. -Renal Impairment: Dosage may need adjustment in patients with renal impairment.
-Hypersensitivity: Contraindicated in individuals with known hypersensitivity to prucalopride or any of its components. -Severe Gastrointestinal Conditions: Not recommended for patients with severe inflammatory bowel disease or bowel obstruction.
-Cardiovascular Conditions: Use with caution in patients with severe cardiovascular disease. -Renal Impairment: Dosage adjustment may be necessary in patients with renal impairment. -Pregnancy and Breastfeeding: The safety of prucalopride during pregnancy and lactation has not been established; it should be used only if the potential benefits outweigh the risks.
-Common: Headache, nausea, abdominal pain, diarrhea. -Less Common: Dizziness, fatigue, and mood changes. -Severe: Severe allergic reactions, signs of bowel obstruction or perforation.
-CYP3A4 Inhibitors: Co-administration with strong CYP3A4 inhibitors (e.g., ketoconazole) may increase prucalopride levels and risk of adverse effects. -CYP3A4 Inducers: May reduce the effectiveness of prucalopride.
