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Quetiapine Fumarate

Quetiapine Fumarate

Antagonist at multiple neurotransmitter receptors in brain, specially 5 HT1a, 5 HT2, D1 & D2, H1 and a1 and a2

Indications

Psychotic Disorders, mood and anxiety disorders, aggression, hostility, Post Traumatic Stress Disorder, delirium.


Dosage

Twice daily. Adults : The total daily dose for the first four days of therapy is 50mg (Day 1), 100mg (Day 2), 200mg (Day 3) and 300mg (Day 4). From day 4 onwards, the dose should be titrated to the usual effective dose range of 300 to 450mg/day.


Contra-Indications

Known history of hypersensitivity to the drug


Special Precautions

Cautious use in patients requiring mental alertness during their jobs such as drivers, pilots etc. Use cautiously in patient predisposed to aspiration pneumonia. Avoid alcohol during therapy.


Side Effects

Orthostatic hypotension with dizziness and syncope, seizuer, dose related decrease in total and free T4. Asymptomatic but reversible increase in serum transaminases, somnolence, priapism.


Drug Interactions

Antihypertensives :Increases the effect of Antihypertensives. Levodopa : Antagonizes Levodopa and dopamine agonists. Phenytoin and other enzyme inducers : Coadministration requires dose to be increased. Ketoconazole increases plasma concentration, Lorazepam : It decreases oral clearance of Lorazepam.


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