Atrial fibrillation or flutter, paroxysmal supra ventricular tachycardia. Ventricular premature beats & ventricular tachycardia. Maintenance of sinus rhythm following electro conversion.
200-300 mg 3-4 times daily. Initially give test dose.
Not recommended for children. Myasthenia gravis. Intolerance or idiosyncrasy to quinidine, heart block, C.H.F. and hypotensive states. History of embolism.
Renal dysfunctions. Paediatric: Not recommended. Pregnancy: No serious effect reported. Lactation: Not recommended. Elderly: Reduced dosage necessary.
Higher doses can cause A.V. dissociation, nausea, vomiting, diarrhoea, cinchonism (ringing in ear, deafness, vertigo, headache, visual disturbances), angioedema, asthma & vascular collapse.
Cimetidine, erythromycin inhibits the hepatic metabolism of quinidine, interaction with beta-blockers causes sinus bradycardia. Amiodarone may increase the plasma concentration of quinidine. Phenobarbitone and rifampicin decreases its effects. Hyperkalemia increases effect of quinidine.