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Quinine sulphate

Quinine sulphate

It is an erythrocytic shizonticide, most chloroquine & multi drug resistant strains of P. falciparum are sensitive to it.


Resistant falciparum malaria, symptomatic relief of muscle cramps, including nocturnal cramps.


Adults: 300-600mg three times daily for 5-7 days. Children: 25 gm/kg/day 8 hourly for 7 days.


Pregnancy, lactation tinnitus, optic neuritis, myasthenia gravis.

Special Precautions

Arterial fibrillation, cinchonism. Haemoglobinuria. Renal or hepatic impairment. Paediatrics: Dose should be reduced. Pregnancy: May cause defects in the developing foetus. Lactation: Drug passes in to breast milk.

Side Effects

Cinchonism, acute haemolytic anaemia, tinnitus headache, blurred vision, vomitting diarrhoea abdominal pain, vertigo.

Drug Interactions

With anti coagulants. Pyrimethamine, digoxin & muscle relaxants

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