Quinine sulphate
It is an erythrocytic shizonticide, most chloroquine & multi drug resistant strains of P. falciparum are sensitive to it.Resistant falciparum malaria, symptomatic relief of muscle cramps, including nocturnal cramps.
Adults: 300-600mg three times daily for 5-7 days. Children: 25 gm/kg/day 8 hourly for 7 days.
Pregnancy, lactation tinnitus, optic neuritis, myasthenia gravis.
Arterial fibrillation, cinchonism. Haemoglobinuria. Renal or hepatic impairment. Paediatrics: Dose should be reduced. Pregnancy: May cause defects in the developing foetus. Lactation: Drug passes in to breast milk.
Cinchonism, acute haemolytic anaemia, tinnitus headache, blurred vision, vomitting diarrhoea abdominal pain, vertigo.
With anti coagulants. Pyrimethamine, digoxin & muscle relaxants
