Ranolazine

Ranolazine is used to treat chest pain. It’s usually used together with other medicines, such as ACE inhibitors, angiotensin receptor blockers, calcium channel blockers, beta-blockers, or nitrates. This medicine is available only with your doctor's prescription.

Indications

Treatment of chronic angina. Ranolazine may be used with beta-blockers, nitrates, calcium channel blockers, anti-platelet therapy, lipid-lowering therapy, ACE inhibitors, and angiotensin, receptor blockers.

Dosage

500mg twice daily and increase to 1000mg twice daily. Swallow Ranolazine tablets whole; do not crush, break, or chew. Limit the maximum dose of Ranolazine to 500mg twice daily in patients on diltiazem, verapamil, and other moderate CYP3A inhibitors.

Contra-Indications

RANEXA is contraindicated in patients: • Taking strong inhibitors of CYP3A • Taking inducers of CYP3A • With liver cirrhosis

Special Precautions

Clinical experience in an acute coronary syndrome population did not show an increased risk of proarrhythmia or sudden death [see Clinical Studies]. However, there is little experience with high doses ( > 1000 mg twice daily) or exposure, other QT-prolonging drugs, potassium channel variants resulting in a long QT interval, in patients with a family history of (or congenital) long QT syndrome, or in patients with known acquired QT interval prolongation.

Side Effects

Dizziness, headache, constipation, nausea, bradycardia, palpitations, tinnitus, vertigo, abdominal pain, dry mouth, vomiting.

Drug Interactions

Ketoconazole, itraconazole, clarithromycin, nefazodone, nelfinavir, ritonavir, indinavir and saquinavir.