Reteplase

-Reteplase is a recombinant tissue plasminogen activator (rt-PA) used as a thrombolytic agent. It is a genetically engineered version of human tissue plasminogen activator, designed to dissolve blood clots by converting plasminogen to plasmin.

Indications

-Reteplase is indicated for the treatment of acute myocardial infarction (heart attack) to restore blood flow to the affected area. It is administered to patients experiencing ST-segment elevation myocardial infarction (STEMI) or other specific types of heart attacks. -Acute ST-elevation myocardial infarction (STEMI).

Dosage

-The dosage of reteplase is weight-based, and it is administered as an intravenous bolus. The specific dosage regimen may vary, and it is crucial to follow the prescribing physician's instructions carefully. -IV; As soon as possible after the onset of STEMI, administer 10 units intravenously over 2 minutes. Administer a second dose of 10 units 30 minutes after the first dose. Reconstitute with sterile water supplied with it.

Contra-Indications

-Reteplase is contraindicated in individuals with a history of hypersensitivity to the drug or any of its components. It is also contraindicated in patients with active bleeding, recent major surgery or trauma, and other conditions where the risk of bleeding is increased. -Active internal bleeding, Recent stroke, Intracranial or intraspinal surgery or serious head trauma within 3 months, Intracranial conditions that increase the risk of bleeding (e.g. neoplasms, arteriovenous malformation, or aneurysms), Bleeding diathesis, Current severe uncontrolled hypertension.

Special Precautions

-Special precautions should be taken in patients with a history of stroke, recent internal bleeding, severe uncontrolled hypertension, or other conditions that may increase the risk of bleeding. Careful monitoring is essential during reteplase administration. -Do not administer along with heparin intravenous line. Paediatric: Safety and efficacy in pediatric patients have not been established. Pregnancy: In animal studies it is associated with increased birth defects and miscarriage. Lactation: Data not sufficient. Elderly: Use with caution.

Side Effects

-Common side effects of reteplase include bleeding, including serious internal bleeding, allergic reactions, and rarely, stroke. Other potential side effects may include nausea, fever, and injection site reactions. -Bleeding, hypersensitivity, cholesterol embolisation.

Drug Interactions

Reteplase may interact with anticoagulant medications, antiplatelet drugs, and other medications that affect blood clotting. It is important to inform the healthcare provider about all medications being taken to avoid potential interactions.