Risedronate Sodium

Risedronate sodium is a bisphosphonate medication used to strengthen bones and treat or prevent osteoporosis. It works by inhibiting the activity of osteoclasts, the cells responsible for breaking down bone tissue, thus helping to maintain bone density and reduce the risk of fractures.

Indications

-Treatment and prevention of osteoporosis in postmenopausal women. -Treatment of osteoporosis in men. -Treatment and prevention of glucocorticoid-induced osteoporosis. -Treatment of Paget's disease of the bone.

Dosage

-Osteoporosis in postmenopausal women: Typically, the dose is 5 mg daily, 35 mg once weekly, or 150 mg once monthly. -Osteoporosis in men: Usually, the dosage is 35 mg once weekly. -Glucocorticoid-induced osteoporosis: The dosage is generally 5 mg daily. -Paget's disease of the bone: The dosage is typically 30 mg daily for 2 months. -Always follow the dosage prescribed by your healthcare provider.

Contra-Indications

-Hypersensitivity to risedronate or any of its components. -Hypocalcemia (low calcium levels in the blood). -Inability to sit or stand upright for at least 30 minutes after taking the medication.

Special Precautions

-Gastrointestinal Issues: Use with caution in patients with esophageal disorders, ulcers, or other gastrointestinal conditions. -Renal Impairment: Use with caution in patients with moderate to severe kidney dysfunction. -Calcium Levels: Monitor calcium levels, as the medication can lower them. -Osteonecrosis of the Jaw: Rare but serious condition that may occur, particularly in cancer patients undergoing invasive dental procedures.

Side Effects

-Common side effects include gastrointestinal issues such as abdominal pain, dyspepsia, acid reflux, and diarrhea. -Other possible side effects include headache, joint or muscle pain, and flu-like symptoms. -Rare but serious side effects include esophageal ulcers and osteonecrosis of the jaw.

Drug Interactions

-Calcium supplements, antacids, and other mineral supplements can interfere with the absorption of risedronate. -Concomitant use with NSAIDs may increase the risk of gastrointestinal irritation.