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Risperidone with Trihexyphenidyl

Risperidone with Trihexyphenidyl

Risperidone is an antipsychotic medication that works by affecting the balance of neurotransmitters in the brain. It is primarily used to treat schizophrenia and bipolar disorder. Trihexyphenidyl, on the other hand, is an anticholinergic medication that helps control symptoms of certain movement disorders.


Risperidone: -Schizophrenia -Bipolar disorder (manic episodes) -Irritability associated with autistic disorder in children and adolescents Trihexyphenidyl: -Parkinson's disease -Extrapyramidal symptoms induced by antipsychotic medications


Risperidone: -Initial dose: 0.5 to 1 mg twice daily -Maintenance dose: 1 to 6 mg per day, adjusted based on response Trihexyphenidyl: -Parkinson's disease: 1 to 2 mg once or twice a day -Extrapyramidal symptoms: 1 mg every 8 to 12 hours, adjusted as needed


Risperidone: -Hypersensitivity to risperidone -Severe renal or hepatic impairment Trihexyphenidyl: -Glaucoma -Myasthenia gravis -Hypersensitivity to trihexyphenidyl

Special Precautions

-Use with caution in elderly patients -Monitor for signs of neuroleptic malignant syndrome (NMS) -Caution in patients with cardiovascular diseases

Side Effects

Risperidone: -Weight gain -Sedation -Extrapyramidal symptoms -Hyperprolactinemia Trihexyphenidyl: -Dry mouth -Blurred vision -Constipation -Urinary retention

Drug Interactions

-Increased risk of sedation when used with other CNS depressants -Potential for additive anticholinergic effects when combined with other anticholinergic drugs

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