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Rivaroxaban

Rivaroxaban



Indications

Rivaroxaban is used to reduce the risk of stroke and blood clots in people with atrial fibrillation, not caused by a heart valve problem. Rivaroxaban is also used to treat deep vein thrombosis and pulmonary embolism, and to help reduce the risk of these conditions occurring again, and to reduce the risk of forming a blood clot in the legs and lungs of people who have just had knee or hip replacement surgery.


Dosage

Oral; 10mg, 15mg,20mg DVT Prophylaxis (Orthopedic Surgery) Indicated for prophylaxis of deep vein thrombosis (DVT), which may lead to pulmonary embolism (PE) in patients undergoing knee or hip replacement surgery Knee replacement: 10 mg orally once/day for 12 days; may take with or without food Hip replacement: 10 mg orally once/day for 35 days; may take with or without food Administer initial dose at least 6-10 hours after surgery once hemostasis has been established Nonvalvular Atrial Fibrillation Indicated to reduce the risk of stroke and systemic embolism in patients with non-valvular atrial fibrillation 20 mg/day orally with the evening meal Deep Vein Thrombosis (DVT) or Pulmonary Embolism (PE) Treatment Indicated for the treatment of DVT and PE 15 mg orally every 12 hours for 21 days with food, THEN 20 mg orally once/day for 6 months Reduce risk for recurrent DVT or PE Indicated to reduce the risk of recurrence of DVT and PE following initial 6 months treatment for DVT and/or PE 20 g orally once/day following initial 6 months of treatment for DVT and/or PE


Contra-Indications

Stop rivaroxaban at least 24 hours before the procedure, Restart rivaroxaban after surgery/procedure as soon as adequate hemostasis is established


Special Precautions

Paediatric: Data not sufficient Pregnancy: Use rivaroxaban with caution during pregnancy if the benefits outweigh the risks. Lactation: It is unknown whether rivaroxaban is distributed in human breast milk; it is not recommended for use while breastfeeding. Elderly: Data not sufficient


Side Effects

Abdominal pain, back pain, bleeding, blister, blood in urine, constipation, diarrhea, dizziness, fainting, fatigue, fever headache, indigestion, itching, muscle pain, muscle spasm, sore throat, UTI, wound secretion, vomiting, Agranulocytosis, Dry mouth, Fatal bleeding, Heavy or prolonged menstrual periods ,Hemorrhage, Hepatitis ,Hives, Increased amylase, Increased BUN, Low blood platelets (thrombocytopenia), Low blood pressure (hypotension), Painful or difficult urination, Retroperitoneal bleeding, Stevens-Johnson syndrome, Weakness of one side of the body, Yellowing skin and eyes (jaundice)


Drug Interactions

defibrotide, prothrombin complex concentrate, human, apixaban, clarithromycin, cobicistat, conivaptan, edoxaban, factor X, human, idelalisib, indinavir, ketoconazole, ritonavir


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