Saxagliptin

It is an orally-active inhibitor of the DPP4 enzyme. Sexagliptin is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diebetes.

Indications

Diabetes mellitus type 2.

Dosage

Oral: 2.5-5mg daily irrespective of meals.

Contra-Indications

Hypersensitivity.

Special Precautions

Paediatric: Safety cannot be established. Pregnancy: Category B; use if needed. Lactation: Not known if secreted in milk, use with caution. Elderly: Renal function may decrease with age so use with caution.

Side Effects

Upper respiratory infection, headache, abdominal pain, low blood sugar (which is most likely to occur if saxagliptin is taken with other diabetes drugs), Sweating, Shakiness, Extreme hunger, dizziness, cold sweats, loss of coordination, difficulty speaking, confusion, seizures, pancreatitis, An unexplained rash, Itching, Unexplained swelling (especially of the lips, mouth or throat), Wheezing or other breathing problems.

Drug Interactions

Ketoconazole, strong CYP3A4/5 inhibitors e.g., Atazanavir, Clarithromycin, Indinavir, Itraconazole, Nefazodone, Nelfinavir, Ritonavir, Saquinavir and Telithromycin.