Simvastatin with Ezetimibe
Simvastatin with Ezetimibe is a combination medication used to treat high cholesterol levels in the blood. It contains two active ingredients, Simvastatin and Ezetimibe, which work together to reduce the production and absorption of cholesterol in the body.-Hypercholesterolemia: To lower elevated total cholesterol, LDL cholesterol, and triglycerides. -Homozygous familial hypercholesterolemia: In combination with a proper diet to reduce elevated total-C and LDL-C levels in patients with this genetic disorder. -Sitosterolemia: To reduce elevated sitosterol and campesterol levels in patients with this rare genetic condition.
The recommended dose may vary based on individual patient needs and medical conditions. It is crucial to follow the prescribed dosage and instructions provided by the healthcare provider.
Simvastatin with Ezetimibe is contraindicated in patients with a known hypersensitivity to any component of the medication, active liver disease, or unexplained persistent elevations of serum transaminases.
-Liver Function: Regular monitoring of liver function is essential, and the medication should be used with caution in patients with a history of liver disease. -Pregnancy and Lactation: Simvastatin with Ezetimibe should be avoided during pregnancy and breastfeeding due to potential harm to the fetus or infant. -Muscle Effects: Patients should be advised to report promptly any unexplained muscle pain, tenderness, or weakness, particularly if accompanied by malaise or fever.
Common side effects may include headache, muscle pain, nausea, and diarrhea. Serious side effects, although rare, may include liver problems and muscle disorders.
-Cyclosporine: Increased risk of myopathy/rhabdomyolysis. -Gemfibrozil: Increased risk of myopathy/rhabdomyolysis. -Amiodarone: Increased risk of myopathy/rhabdomyolysis.
