Septicaemia, Respiratory, urinary tract infections. Burns.
3 mg/kg body wt in 3 divided doses.
Hypersensitivity to amino- glycosides.
Renal impairment. Drug interaction occurs with other aminoglycosides, cephalo-sporins, amphotericin, cephalothin, vancomycin, cisplatin, methoxyflurane, diuretics, anaesthetics. Paediatrics: Use with caution. Pregnancy: Contraindicated. Lactation: Contraindicated. Elderly: Use with caution.
Ototoxicity and nephrotoxicity, Proteinuria azotemia, oliguria, tinnitus, ataxia, vertigo, deafness, C.N.S disturbances , convulsions, tremor, nystagmus
Potentiates nephrotoxicity produced by drugs like aminoglycosides vancomycin and some cephalosporins & ototoxicity produced by drugs like aminoglycosides, ethacryanic acid. Plasma levels increased by indomethacin . Incompatible with some betalactam antibiotics.