Treatment of HIV-infected patients who have received prolonged prior zidovudine therapy.
Adults: 40mg twice daily for patients ³ 60 kg. 30mg twice daily for patients han 30 kg is 1mg/kg/dose, given every 12 hours. Patients should be monitored for the development of peripheral neuropathy.
Lactic acidosis/severe hepatomegaly with steatosis, Peripheral neuropathy, Pregnancy, Nursing mothers, Renal Insufficiency.
Peripheral neuropathy, elevation of hepatic transaminases, headache, chills/fever, diarrhoea, rash, nausea and vomiting, abdominal pain, pancreatitis, myalgia and insomnia.