STERILE MEDROXYPROGESTRONE ACETATE SUSP.

Indications

Contraception (Ovulation suppression), endometriosis, adjunctive or palliative treatment for recurrent and/or metastatic breast endometrial or renal carcinoma; menopausal vasomotor symptoms.

Dosage

Contraception: 150mg every 3 months by deep, i.m. injection. Endometriosis: 50mg weekly or 100mg every 2 wks i.m. for atleast 6 months. Endometrial or renal carcinoma: 400 to 1000mg i.m. ry wk.Breast cancer: 500mg/day i.m. for 28 days. Menopausal symptoms: 150mg i.m. every 12 wks.

Contra-Indications

Patients sensitive to steriods, pregnacy.

Special Precautions

Exclude breast or genital neoplasia, thromboembolic disorder. Patient may develop weight gain & fluid retention. High doses used in the treatment of cancer patients may cause Cushingoid symptoms.

Side Effects

Anaphylaxis and anaphylactoid reactions; thromboembolic disorders; nervousness, insomnia, somnolence, fatigue, depression, dizziness and headache, urticaria, pruritus, rash, acne, hirsutism, alopecia, nausea, breast tenderness and galactorrhea.

Drug Interactions

Concomitant aminoglutethimide administration may reduce bioavailability.