SULPHADIAZINE

Sulphadiazine is a sulfonamide antibiotic used to treat various bacterial infections. It works by inhibiting the growth and multiplication of bacteria.

Indications

Sulphadiazine is indicated for the treatment of urinary tract infections, respiratory tract infections, gastrointestinal infections, and certain types of skin infections caused by susceptible bacteria.

Dosage

The dosage of sulphadiazine depends on the severity of the infection, the patient's age, and medical condition. It is typically taken orally, with or without food, as directed by a healthcare professional.

Contra-Indications

Sulphadiazine is contraindicated in individuals with a history of hypersensitivity to sulfonamide antibiotics or any of the ingredients in the formulation. It should not be used in patients with severe hepatic or renal impairment, blood dyscrasias, or porphyria.

Special Precautions

Patients taking sulphadiazine should stay adequately hydrated to prevent crystalluria. It should be used with caution in individuals with a history of allergies, asthma, or glucose-6-phosphate dehydrogenase (G6PD) deficiency. Sulphadiazine may increase the risk of photosensitivity reactions, so patients should avoid prolonged sun exposure and use sunscreen.

Side Effects

Common side effects of sulphadiazine include nausea, vomiting, diarrhea, headache, dizziness, and skin rash. Rare but serious side effects may include blood disorders, liver or kidney damage, and severe allergic reactions. Patients experiencing any adverse effects should seek medical attention promptly.

Drug Interactions

Sulphadiazine may interact with certain medications, including oral anticoagulants, phenytoin, methotrexate, and certain diuretics. It is important to inform the healthcare provider about all medications, supplements, and herbal products being taken to avoid potential interactions.