SULPHADIMIDINE

Sulphadimidine is a sulfonamide antibiotic used to treat various bacterial infections. It inhibits the growth and multiplication of bacteria by interfering with the synthesis of folic acid, which is essential for bacterial DNA replication and cell division.

Indications

-Respiratory tract infections -Urinary tract infections -Gastrointestinal infections -Soft tissue infections -Bacterial meningitis

Dosage

The dosage of Sulphadimidine varies based on the type and severity of the infection, age, weight, and kidney function of the patient. It is important to follow the prescribing physician’s recommendations and the instructions on the medication label.

Contra-Indications

-Hypersensitivity to sulfonamides -Severe renal or hepatic impairment -Porphyria -Infants less than 2 months old

Special Precautions

-Use with caution in patients with renal or hepatic impairment -Maintain adequate fluid intake to prevent crystalluria and kidney damage -Regular blood counts should be performed during long-term therapy -Monitor for signs of hypersensitivity reactions

Side Effects

-Nausea and vomiting -Diarrhea -Rash and pruritus -Blood disorders such as agranulocytosis, thrombocytopenia -Crystalluria and kidney damage

Drug Interactions

-Anticoagulants: Enhanced effect of anticoagulants -Methotrexate: Increased risk of methotrexate toxicity -Phenytoin: Increased phenytoin levels -Oral hypoglycemics: Enhanced hypoglycemic effect -Other sulfonamides: Increased risk of sulfonamide toxicity