SULPHADOXINE

Sulphadoxine is a sulfonamide antibiotic used primarily to treat and prevent bacterial infections. It is often combined with pyrimethamine in a fixed-dose combination for the treatment of malaria.

Indications

-Malaria: Used in combination with pyrimethamine to treat and prevent malaria. -Bacterial Infections: May be used in the treatment of certain bacterial infections, especially when other antibiotics are not suitable.

Dosage

-Malaria: Typically administered as a combination with pyrimethamine. The dosage and duration depend on the specific malaria protocol. -Bacterial Infections: Dosage varies based on the type and severity of the infection. Follow the specific dosing instructions provided by a healthcare professional.

Contra-Indications

-Allergy: Known hypersensitivity to sulfonamides or sulfonamide derivatives. -Severe Liver or Kidney Disease: Use is contraindicated in patients with severe liver or kidney impairment.

Special Precautions

-Pregnancy and Lactation: Consult with a healthcare provider as use during pregnancy and breastfeeding may be contraindicated or require careful monitoring. -G6PD Deficiency: Caution is advised in patients with glucose-6-phosphate dehydrogenase deficiency.

Side Effects

-Common: Nausea, vomiting, diarrhea, rash. -Severe: Severe allergic reactions, liver toxicity, bone marrow suppression, renal impairment.

Drug Interactions

-Anticoagulants: May enhance the effects of anticoagulants. -Methotrexate: Increased risk of toxicity when used in combination. -Other Antibiotics: Potential interactions with other antibiotics, which may alter efficacy or increase side effects.