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Sulfamethopyrazine with pyrimethamine is a combination medication that typically contains a sulfonamide (sulfamethopyrazine) and an antimalarial agent (pyrimethamine). This combination is often used for the treatment of certain parasitic infections, particularly those caused by protozoa.


This combination is indicated for the treatment of specific parasitic infections, including toxoplasmosis and malaria. It works by inhibiting the growth and replication of the parasites.


Dosage may vary depending on the specific condition being treated. It's crucial to follow the prescribed dosage and duration of treatment as directed by a healthcare professional.


Patients with a history of hypersensitivity or allergic reactions to sulfonamides, pyrimethamine, or related compounds should not use this medication. Pregnant women, especially during the first trimester, may need to avoid pyrimethamine due to potential risks.

Special Precautions

-Individuals with a history of blood disorders or folate deficiency may require special monitoring. -Caution is advised in patients with renal or hepatic impairment. -Adequate folate supplementation may be necessary to prevent folate deficiency-related side effects.

Side Effects

Common side effects may include nausea, vomiting, rash, and allergic reactions. Severe side effects such as blood disorders and liver toxicity are rare but possible.

Drug Interactions

Potential interactions with other medications, such as anticoagulants or anticonvulsants, may occur. It's essential to inform healthcare providers about all medications being taken, including over-the-counter drugs and supplements.

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