Tacrolimus

Indications

Prophylaxis of organ rejection in patients receiving allogenic liver or kidney transplants.

Dosage

Kidney transplantation : 0.2mg/kg/day in adults as two divided doses taken every 12 hrs. Liver transplantation : 0.10-0.15mg/kg/day in two divided doses taken every 12 hrs. Maintenance dosage should be individualized so as to maintain whole blood concentration between 5-20ng/ml Children : Generally need doses 1.5 to 2 times greater than those in adults.

Drug Interactions

inhibitor or inducer of CYP3A, CYP2D6