Tazarotene

Tazarotene is a prodrug that is de-esterified in the skin to its active form tazarotenic acid which appears to modulate cell proliferation and differentiation.

Indications

It is a retinoid used for the topical treament of mild to moderate acne & plague psoriasis.

Dosage

Adult: Apply 0.05% or 0.1% gel once daily in the evening.

Contra-Indications

Pregnancy, lactation, Eczema, Sunburnt conditions. Hypersensitivity.

Special Precautions

Avoid contact with eyes, mouth, mucous membrances. Abraded skin. Avoid exposure to sun or UV light. Use on 20% of body surface area. Dosing frequency, tolerance, therapeutic response must be monitored during treatment. Do not use cream with occlusive dressing. Wash hands after application. Do not use cream/gel in amounts more than instructed.

Side Effects

Pruritus, burning/Stinging, erythema, skin peeling, irritation, worsening of psoriasis, rash, dry skin, bleeding, peripheral oedema, hypertriglyceridaemia, desquamation, contact dermatitis, temporary hypoand hyperpigmentation. Photosensitivity, Rarely, inflamed, dry or painful skin.

Drug Interactions

Concomitant use with dermatologic medications and cosmetics that have an irritant or strong drying effect. Risk of benign intracranial hypertension with tetracyclines. Risk of benign intracranial hypertension with tetracyclines. Risk of hypervitaminosis with vitamin A.