Severity: Warning
Message: fopen(/var/cpanel/php/sessions/ea-php74/ci_session11e32f87cbdc659790b155edb7a62f4726ac2340): failed to open stream: No space left on device
Filename: drivers/Session_files_driver.php
Line Number: 176
Backtrace:
File: /home/drugtodayonline/public_html/application/controllers/Drug_directory.php
Line: 9
Function: __construct
File: /home/drugtodayonline/public_html/index.php
Line: 311
Function: require_once
Severity: Warning
Message: session_start(): Failed to read session data: user (path: /var/cpanel/php/sessions/ea-php74)
Filename: Session/Session.php
Line Number: 143
Backtrace:
File: /home/drugtodayonline/public_html/application/controllers/Drug_directory.php
Line: 9
Function: __construct
File: /home/drugtodayonline/public_html/index.php
Line: 311
Function: require_once
TEMOZOLOMIDE
Temozolomide is an imidazotetrazine alkylating agent with antituour activity. It undergoes rapid chemical conversion in the systemic circulation at physiological pH to the active compound, monomethyl triazeno iidazole carboxamide (MTIC). The cytotoxicity of MTIC is thought to be due promarily to alkylation at the O6 Position of guanine with addtional alkylation also occurring at the N7 Position. Cytotoxic lesions that develop subsequently are through to involve aberrant repair of the methyl adduct.Patients with newly diagnosed glioblastoma multiforme concomitantly with radiotherapy and then as adjuvant treatment. Patiets with recurrent high grade glooma, such as glioblastoma multiforme or anaplastic astrocytoma, patients with advanced metastatic malignant melanoma.
Concomitant phase consists of Temozolomide adiministered orally at 75mg/m2 daily for 42 days with focal adiotherapy (60Gy administered in 30 fractions) The concomitant phase is followed by the adjuvant phase (Temozolomide for 6 cycles).
Contraindicated in the case of hypersensitivity, in pregnancy, in Lactation & in patient with severe myelosuppression.
Administration of Temozolomide with ranitidine did not result in clinically significant alterations in the extent of absorption of Temozolomide. Co-administration of dexamethasone, prochlorperazine, phenytoin, carbamazepine, ondansetron, H2-receptor antagonists or phenobarbital did not alter the clearance of Temozolomide. Co-administration with valproic acid was associated with a small but statistically significant decrease ub clearance of Temozolomide. use of Temozolomide in combination with ot
Severity: Warning
Message: mysqli::query(): (HY000/1): Can't create/write to file '/tmp/#sql_3e5_0.MYI' (Errcode: 28 - No space left on device)
Filename: mysqli/mysqli_driver.php
Line Number: 307
Backtrace:
File: /home/drugtodayonline/public_html/application/models/Site_ads_model.php
Line: 118
Function: query
File: /home/drugtodayonline/public_html/application/libraries/Common_lib.php
Line: 318
Function: get_front_ads_data
File: /home/drugtodayonline/public_html/application/views/front/salt_info.php
Line: 165
Function: common_footer_ads
File: /home/drugtodayonline/public_html/application/controllers/Drug_directory.php
Line: 331
Function: view
File: /home/drugtodayonline/public_html/application/controllers/Drug_directory.php
Line: 29
Function: drug_info
File: /home/drugtodayonline/public_html/index.php
Line: 311
Function: require_once
Severity: Warning
Message: Cannot modify header information - headers already sent by (output started at /home/drugtodayonline/public_html/system/core/Exceptions.php:271)
Filename: core/Common.php
Line Number: 570
Backtrace:
File: /home/drugtodayonline/public_html/application/models/Site_ads_model.php
Line: 118
Function: query
File: /home/drugtodayonline/public_html/application/libraries/Common_lib.php
Line: 318
Function: get_front_ads_data
File: /home/drugtodayonline/public_html/application/views/front/salt_info.php
Line: 165
Function: common_footer_ads
File: /home/drugtodayonline/public_html/application/controllers/Drug_directory.php
Line: 331
Function: view
File: /home/drugtodayonline/public_html/application/controllers/Drug_directory.php
Line: 29
Function: drug_info
File: /home/drugtodayonline/public_html/index.php
Line: 311
Function: require_once
Error Number: 1
Can't create/write to file '/tmp/#sql_3e5_0.MYI' (Errcode: 28 - No space left on device)
SELECT * FROM `dt_site_ads` WHERE `status` = '1' and `loc` = 'pre_footer_4' ORDER BY RAND() LIMIT 0,1
Filename: models/Site_ads_model.php
Line Number: 118