Terazosin
It is an a-1 adenoceptor antagonist used in treatment of hypertension. It reduces serum cholesterol LDL & VLDL cholesterol levels.Mild to moderate hypertension, Symptomatic relief of urinary obstruction in patients with BPH.
1 mg at bed time, increased every week if required. Maintenance dose 2-10 mg per day. Max. 20 mg/day.
Hypersensitivity.
Considering the severe hypotension with first dose, the dose should be low. Prostatic cancer & BPH cause similar symptoms, liver disease & those receiving antihypertensives. Paediatrics: Use only, if clearly indicated. Pregnancy: Safety has not been established. Lactation: Caution should be taken. Elderly: The dose to be reduced, may cause exaggeration of side effects.
Hypotension ,dizziness, drowsiness, nausea, blurred vision and oedema.
Beta blockers , diuretics & calcium channel blockers may increase the incidence of orthostatic hypotension.
