Terazosin

Terazosin is an alpha-1 blocker medication used primarily to treat hypertension (high blood pressure) and benign prostatic hyperplasia (BPH). It works by relaxing blood vessels and muscles in the prostate and bladder neck, leading to improved urine flow and reduced blood pressure. It is an a-1 adenoceptor antagonist used in treatment of hypertension. It reduces serum cholesterol LDL & VLDL cholesterol levels.

Indications

Mild to moderate hypertension, Symptomatic relief of urinary obstruction in patients with BPH.

Dosage

1 mg at bed time, increased every week if required. Maintenance dose 2-10 mg per day. Max. 20 mg/day.

Contra-Indications

-Hypersensitivity to terazosin or any alpha blockers -Orthostatic hypotension -History of syncope (fainting) -Severe hepatic impairment

Special Precautions

Considering the severe hypotension with first dose, the dose should be low. Prostatic cancer & BPH cause similar symptoms, liver disease & those receiving antihypertensives. Paediatrics: Use only, if clearly indicated. Pregnancy: Safety has not been established. Lactation: Caution should be taken. Elderly: The dose to be reduced, may cause exaggeration of side effects.

Side Effects

-Dizziness -Headache -Fatigue -Drowsiness -Orthostatic hypotension -Palpitations -Nasal congestion -Edema -Ejaculation disorders -Priapism (rare)

Drug Interactions

-Antihypertensive medications: Enhanced hypotensive effects. -Phosphodiesterase-5 inhibitors (e.g., sildenafil, tadalafil): Increased risk of symptomatic hypotension. -Alpha blockers: Increased risk of hypotension and orthostatic effects. -CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): Increased terazosin levels. -NSAIDs and alcohol: Enhanced hypotensive effects. -Beta blockers , diuretics & calcium channel blockers may increase the incidence of orthostatic hypotension.