Tezacaftor
Tezacaftor is a medication used to treat cystic fibrosis, a genetic disorder that affects the lungs and digestive system. It works by correcting the function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein in certain patients with specific CFTR gene mutations. Tezacaftor is often used in combination with other CFTR modulators to improve lung function and other symptoms in individuals with cystic fibrosis.Tezacaftor is indicated for the treatment of cystic fibrosis in patients with specific CFTR gene mutations. It is typically used in combination with other CFTR modulators, such as ivacaftor.
The dosage of tezacaftor varies depending on the patient's age and the specific CFTR gene mutations they have. It's usually taken orally once daily and often combined with other CFTR modulators like ivacaftor. Always follow the healthcare provider's dosing instructions.
Tezacaftor should not be used in patients with known hypersensitivity to tezacaftor or any of its components. It is also contraindicated in patients who are taking certain medications that can affect the levels of tezacaftor in the body.
Special care should be taken in patients with liver impairment, as tezacaftor may impact liver function. Regular monitoring of liver enzymes is recommended. It is essential to consult a healthcare provider before using tezacaftor if the patient is pregnant, planning to become pregnant, or breastfeeding.
Common side effects of tezacaftor may include headache, nausea, nasal congestion, or dizziness. Liver enzyme elevations may also occur, so regular monitoring is important. Severe side effects may include symptoms of liver dysfunction or allergic reactions.
Tezacaftor can interact with certain medications, including some antibiotics, antifungals, and seizure medications. It can also interact with grapefruit and Seville oranges, which may impact its effectiveness. It's essential to consult a healthcare provider about potential drug interactions before starting treatment.
