THIACETAZONE

Thiacetazone is a medication primarily used as an antitubercular agent. It is used in the treatment of tuberculosis, often in combination with other drugs to enhance efficacy and prevent resistance.

Indications

-Tuberculosis (TB) in combination with other antitubercular medications -Leprosy, in combination with other drugs

Dosage

-Adult Dosage: Typically 300 mg once daily or as directed by a healthcare provider. -Pediatric Dosage: Dosage for children is adjusted based on body weight and specific clinical condition.

Contra-Indications

-Known hypersensitivity to Thiacetazone or any component of the formulation -Severe liver or kidney impairment

Special Precautions

-Monitor liver function and renal function regularly. -Use with caution in patients with a history of liver disease. -Patients with diabetes mellitus should be monitored for potential blood sugar changes. -Avoid alcohol as it can exacerbate side effects.

Side Effects

-Common: Nausea, vomiting, dizziness, headache -Serious: Hepatotoxicity, severe allergic reactions, skin rashes, jaundice -Rare: Hematological disorders, peripheral neuropathy

Drug Interactions

-May interact with other antitubercular drugs, such as Rifampicin and Isoniazid. -Caution with drugs metabolized by the liver; may require dosage adjustments. -May affect the effectiveness of oral contraceptives.