Ticlopidine with Aspirin

Ticlopidine and Aspirin combination is a medication that includes ticlopidine hydrochloride, an antiplatelet agent, and aspirin, a nonsteroidal anti-inflammatory drug (NSAID). Together, they work synergistically to prevent blood clot formation.

Indications

This combination is prescribed for the prevention of vascular events, especially in patients with a history of stroke, myocardial infarction (heart attack), or peripheral vascular disease. It helps reduce the risk of thrombotic events by inhibiting platelet aggregation.

Dosage

The dosage may vary based on the individual's medical condition and the prescribing physician's recommendations. Typically, the standard dose is ticlopidine 250 mg twice daily and aspirin 75-100 mg once daily.

Contra-Indications

This combination is contraindicated in individuals with a history of hypersensitivity to ticlopidine, aspirin, or other NSAIDs. It is also contraindicated in patients with active bleeding disorders or peptic ulcers.

Special Precautions

-Caution is advised in patients with a history of gastrointestinal bleeding or ulcer disease. -Regular monitoring of blood counts is recommended due to the potential for ticlopidine to cause neutropenia. -The combination should be used cautiously in patients with hepatic or renal impairment.

Side Effects

Common side effects may include gastrointestinal upset, dyspepsia, bleeding tendencies, rash, and neutropenia. Serious side effects such as thrombotic thrombocytopenic purpura (TTP) have been reported but are rare.

Drug Interactions

There are potential interactions with other drugs, including anticoagulants, nonsteroidal anti-inflammatory drugs (NSAIDs), and certain antacids. Close monitoring and dosage adjustments may be necessary when combining with these medications.