TIGECYCLINE

The first clinically available drug in a new class antibiotic, glycylcycline antibiotic. It is active against many Gram-positive bacteria, Gram-negative bacteria and anaerobes including activity against (MRSA), Stenotrophomonas maltophilia, Haemophilus influenzae, and Neisseria gonorrhoeae and multidrug resistant strains of Acinetobacter baumannii. The New Delhi metallo-b-lactamase multidrug resistant Enterobacteriaceae has also shown susceptibility to tigecycline.

Indications

Treatment of complicated skin and soft tissue infections as well as complicated intra-abdominal infections.

Dosage

Given by slow intravenous infusion (30 to 60 minutes). A sigle dose of 100mg is given first followed by 50mg every tweleve hours after that

Contra-Indications

Hypersensitivity to tigecycline.

Special Precautions

Anaphylaxis/Anaphylactoid reactions, Hepatic effects, Mortality Imbalance and lower cure rates in ventilator-associated Pneumonia, photosensitivity, pseudotumor cerebri, pancreatitis, and anti-anabolic action which has led to increased BUN, azotemia, acidosis, and hyperphosphataemia. Use during pregnancy: May cause fetal harm when administered to a pregnant women. Avoid use in children and pregnancy, due to its effects on teeth and bone

Side Effects

Diahhrea, nausea and vomiting, diziness, phlebitis, elevated (AST) and (ALT), pruritis, rash, headache, Pseudomembranous colitis. Other side effects include pain at the injection site, swelling and irritation, increased or decreased heart rate and infections

Drug Interactions

Warfarin, Oral contraceptives.