TOBRAMYCIN SULPHATE
It is an aminogly-coside that acts by inhibiting the synthesis of protein in bacterial cells.Septicemia, Lower respiratory tract infections, meningitis, Intra-abdominal infections, urinary tract infections
Adults with serious infections :-3 mg/kg/day, administered in 3 equal doses every 8 hours Adults with life-threatening infections- Upto 5mg/kg/day, in 3 or 4 equal doses. Children 6 to 7.5mg/kg/day in 3 or 4 equally divided doses (2 to 2.5mg/kg/ every 8 hours or 1.5 to 1.89 mg/kg/ every 6 hours. Premature or full-term neonates one week of age of less-Upto 4mg/kg/day may be administered in 2 equal doses every 12 hours
Hypersensitivity
Ototoxicity and nephrotoxicity, premature and neonatal infants, should not be given concurrently with potent diuretics, such as ethacrynic acid and frusemide. Serum calcium, magnesium and sodium should be monitored. Paediatrics: Safety not clearly established. Pregnancy: Contraindicated. Lactation: Contraindicated. Elderly: Use with caution.
Neurotoxicity, on both the vestibular & auditory branches of the eighth nerve, Nephrotoxicity, granulocytopenia & thrombocytopenia, fever, rash, exfoliative dermatitis, itching, urticaria, nausea, vomiting, diarrhoea, headache.
Ethacrynic acid and other neuromuscular blocking drugs increases the nephrotoxicity and ototoxicity. penicillins, cephalosporins and newer beta-lactam antibiotics increases the action of tobramycin.
