TOFISOPAM

Tofisopam is an atypical benzodiazepine, structurally related to 1,4-benzodiazepines. It possesses anxiolytic properties, but unlike other benzodiazepines, it is not sedative, or anticonvulsant, or muscle relaxant and has little effect on motor skills and low amnesic properties.

Indications

-Generalized anxiety disorder (GAD) -Stress-induced anxiety -Anxiety associated with depression -Somatic symptoms of anxiety

Dosage

-Adults: The usual dosage is 50 mg to 100 mg, taken two to three times daily, depending on the severity of the condition and individual response. -Elderly or Patients with Liver Impairment: Dosage adjustments may be necessary. Start with the lower end of the dosage range.

Contra-Indications

-Hypersensitivity to Tofisopam or any component of the formulation -Severe liver impairment -Severe renal impairment -Pregnant or breastfeeding women (unless benefits outweigh risks)

Special Precautions

-Sleep disturbance may occur -Paediatric: Data not sufficient -Pregnancy: Not recommended -Lactation: Data not sufficient -Elderly: Data not sufficient

Side Effects

-Drowsiness -Dizziness -Dry mouth -Fatigue -Gastrointestinal disturbances (nausea, constipation)

Drug Interactions

-May interact with other CNS depressants (e.g., alcohol, benzodiazepines, opioids), increasing the risk of sedation and respiratory depression. -Potential interaction with certain antidepressants and antiepileptics. -Monitor for interactions with medications that affect liver enzymes.