Topiroxostat

Topiroxostat is a medication that inhibits xanthine oxidase, an enzyme involved in the production of uric acid. It is used primarily in the management of hyperuricemia (elevated levels of uric acid in the blood) associated with gout.

Indications

-Treatment of hyperuricemia in patients with gout who have not achieved target serum uric acid levels with conventional therapy (e.g., allopurinol). -Prevention of gout flares and reduction of uric acid crystal formation in joints and tissues.

Dosage

-The dosage of topiroxostat is typically initiated at 160 mg once daily, with adjustments based on individual patient response and serum uric acid levels. -It is taken orally with or without food.

Contra-Indications

-Hypersensitivity to topiroxostat or any component of the formulation. -Severe renal impairment (creatinine clearance less than 30 mL/min) due to potential risk of drug accumulation.

Special Precautions

-Monitor renal function regularly during treatment, especially in patients with pre-existing renal impairment. -Use with caution in patients with hepatic impairment or history of cardiovascular disease. -Avoid concurrent use with other medications that may interact or exacerbate renal or hepatic function.

Side Effects

Common side effects may include: -Headache -Gastrointestinal disturbances (nausea, diarrhea) -Elevated liver enzymes -Skin rash or allergic reactions

Drug Interactions

-Topiroxostat may interact with drugs that affect renal function or hepatic metabolism, including other medications used to treat gout (e.g., allopurinol, febuxostat). -Caution is advised when combining with drugs metabolized by CYP3A4 or drugs that may increase the risk of renal toxicity.