TRANEXAMIC

It produces an antifibrinolytic effect by competitively inhibiting the activation of plasminogen to plasmin.

Indications

Prevention of bleeding after surgery or trauma, prevention of rebleeding of subarachnoid hemorrhage, primary or intrauterine contraceptivedevice (IUCD)-induced menorrhagia, gastric and intestinal hemorrhage, recurrent epistaxis, spontaneous or postoperative corneal edema, hereditary angioneurotic edema, non-hereditary angioedema, bleeding in acute promyelocytic leukemia, bleeding after cardiopulmonary bypass.

Dosage

Oral, local fibrinolysis, 15-25mg/kg 2-3 times dialy. Menorrhagia (initiated when heavy bleeding has started), 1-1.5g 3-4 times daily for 3-4 days. Hereditary angioedema, 1-1.5g 2-3 times daily by slow intravenous injection, local fibrinolysis, 0.5-1g 3 times daily. Following surgery : a dose of 25mg per kg body weight given orally three or four times daily for 2 to 8 days.

Contra-Indications

Patients with renal fialure, Massive upper urinary tract hemorrhage, pregnancy and lactation, discontinue in any patient who develops a colour vision defect, thrombophlebitis, impaired liver function, subarachnoid bleeding

Special Precautions

Do not take tranexamic if you: Currently have a blood clot Have ever had a blood clot Have been told that you are at risk of having a blood clot Are taking combination hormonal contraceptive medication Are allergic to tranexamic

Side Effects

Diarrhea, nausea, vomiting, blurred vision, hypotension, thromboembolism and thrombosis.

Drug Interactions

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Tranexamic and other medicines can affect each other, causing side effects.