Tranylcypromine

Tranylcypromine is a medication belonging to the class of monoamine oxidase inhibitors (MAOIs), primarily used in the treatment of depression. Tranylcypromine is an antidepressant medication that works by inhibiting the enzyme monoamine oxidase, thus increasing the levels of certain neurotransmitters in the brain, such as serotonin, norepinephrine, and dopamine.

Indications

-Major depressive disorder (MDD) -Treatment-resistant depression -Atypical depression

Dosage

Dosage may vary depending on individual patient response and medical condition. Typically, initial doses range from 10 to 30 mg per day, with adjustments made under medical supervision.

Contra-Indications

-Hypersensitivity to tranylcypromine or any component of the formulation -Concurrent use with other MAOIs or within 14 days of discontinuing other MAOIs -Pheochromocytoma -Cardiovascular disease -History of liver disease

Special Precautions

-Use with caution in patients with a history of seizure disorders -Avoid consuming foods high in tyramine (e.g., aged cheeses, cured meats) and sympathomimetic agents to prevent hypertensive crisis -Monitor blood pressure regularly during treatment

Side Effects

Common side effects may include: Dizziness, Drowsiness, Insomnia, Dry mouth, Constipation, Orthostatic hypotension, Sexual dysfunction

Drug Interactions

Tranylcypromine may interact with: -Other antidepressants -Sympathomimetic agents -Serotonergic agents -Medications containing tyramine -CNS depressants