Triamterene and Amiloride
They are two nonsteroidal organic ashes which act on distal tubule by blocking sodium, potassium and hydrogen exchange. They decrease potassium excretion. Their action is not depndent on secretion of aldosterone. Both are used in conjunction with thiazide type or high ceiling diuretics to prevent hypokalemia and slightly augment the natriuretic response.Oedema, mild to moderate hypertension Hepatic Cirrhosis with ascites, CCF & nephrotic syndrome.
Initial dose: 100 mg orally 2 times a day after meals Maximum dose: 300 mg/day
Hyperkalaemia, severe or progressive renal failure, potassium supplements.
Diabetes, acidosis, renal or hepatic dysfunction, gout, pregnancy, lactation.
Nausea, diarrhoea, cramps, weakness, rash, headache, dry mouth, blood dyscrasias.
Potentiates anti-hypertensives. Probenecid competitively inhibits tubular secretion. NSAIDs may reduce the diuretic effect of hydrochlorothiazide. Adverse effects may be increased with digoxin if excessive potassium is lost. Corticosteroids increase the loss of potassium from the body.
