Oedema, mild to moderate hypertension Hepatic Cirrhosis with ascites, CCF & nephrotic syndrome.
Initial dose: 100 mg orally 2 times a day after meals Maximum dose: 300 mg/day
Hyperkalaemia, severe or progressive renal failure, potassium supplements.
Diabetes, acidosis, renal or hepatic dysfunction, gout, pregnancy, lactation.
Nausea, diarrhoea, cramps, weakness, rash, headache, dry mouth, blood dyscrasias.
Potentiates anti-hypertensives. Probenecid competitively inhibits tubular secretion. NSAIDs may reduce the diuretic effect of hydrochlorothiazide. Adverse effects may be increased with digoxin if excessive potassium is lost. Corticosteroids increase the loss of potassium from the body.