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Triamterene and Amiloride

Triamterene and Amiloride

They are two nonsteroidal organic ashes which act on distal tubule by blocking sodium, potassium and hydrogen exchange. They decrease potassium excretion. Their action is not depndent on secretion of aldosterone. Both are used in conjunction with thiazide type or high ceiling diuretics to prevent hypokalemia and slightly augment the natriuretic response.


Oedema, mild to moderate hypertension Hepatic Cirrhosis with ascites, CCF & nephrotic syndrome.


Initial dose: 100 mg orally 2 times a day after meals Maximum dose: 300 mg/day


Hyperkalaemia, severe or progressive renal failure, potassium supplements.

Special Precautions

Diabetes, acidosis, renal or hepatic dysfunction, gout, pregnancy, lactation.

Side Effects

Nausea, diarrhoea, cramps, weakness, rash, headache, dry mouth, blood dyscrasias.

Drug Interactions

Potentiates anti-hypertensives. Probenecid competitively inhibits tubular secretion. NSAIDs may reduce the diuretic effect of hydrochlorothiazide. Adverse effects may be increased with digoxin if excessive potassium is lost. Corticosteroids increase the loss of potassium from the body.

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