TRIMETHOPRIME
TRIMETHOPRIME is an antibiotic medication used for treating bacterial infections. It combines Trimethoprim, a dihydrofolate reductase inhibitor, with a sulfamethoxazole component to provide broad-spectrum antibacterial activity.-Urinary tract infections -Respiratory tract infections -Gastrointestinal infections -Otitis media -Certain types of pneumonia
-Adults: Typically, one tablet every 12 hours for 10-14 days, or as prescribed by a healthcare provider. -Children: Dosage is based on body weight and severity of infection. Generally, a pediatric dose is determined by a healthcare professional.
-Hypersensitivity to Trimethoprim, Sulfamethoxazole, or other sulfonamides. -Severe liver disease or renal impairment. -Pregnancy (especially during the first trimester) and breastfeeding unless advised by a healthcare provider.
-Monitor renal function regularly. -Use cautiously in patients with a history of allergic reactions to sulfonamides or trimethoprim. -Ensure adequate hydration to reduce the risk of crystalluria.
-Common: Nausea, vomiting, rash, and loss of appetite. -Serious: Severe skin reactions (e.g., Stevens-Johnson syndrome), liver enzyme abnormalities, blood dyscrasias.
-May interact with anticoagulants like warfarin, increasing bleeding risk. -Potential interaction with methotrexate, increasing its toxicity. -May affect the efficacy of certain vaccines and other medications.-Co-administration with pyrimethamine causes megaloblastic anaemia.
