Ulinastatin

Ulinastatin is a protease inhibitor with anti-inflammatory and anti-oxidative properties. It is derived from human urine and functions primarily by inhibiting various proteases and cytokines involved in inflammatory processes. It is used in various medical conditions to mitigate inflammatory damage and improve outcomes in critically ill patients.

Indications

-Sepsis: Reduces inflammatory damage and organ dysfunction in sepsis. -Acute Pancreatitis: Decreases systemic inflammation and organ damage. -Acute Respiratory Distress Syndrome (ARDS): Helps manage inflammation in ARDS. -Post-surgical Inflammation: Used to control inflammation and improve recovery in major surgeries. -Renal Failure: May be used to manage inflammation associated with acute renal failure.

Dosage

-Adults: Typically administered intravenously at a dose of 10,000 to 50,000 units per day, depending on the condition being treated. Dosage adjustments are made based on the severity of the condition and patient response. -Children: Dosage should be adjusted according to weight and clinical condition; consult a specialist for precise dosing.

Contra-Indications

-Allergy: Hypersensitivity to ulinastatin or any component of the formulation. -Pregnancy and Breastfeeding: Safety during pregnancy and breastfeeding has not been established; use only if the potential benefit justifies the potential risk.

Special Precautions

-Renal Impairment: Use with caution in patients with renal impairment as it may affect drug metabolism and clearance. -Liver Function: Monitor liver function during treatment, as impaired liver function may influence drug efficacy and safety. -Allergic Reactions: Monitor for signs of allergic reactions, including rash or anaphylaxis.

Side Effects

-Common: Fever, chills, headache, and nausea. -Less Common: Allergic reactions, rash, hypotension, and gastrointestinal discomfort. -Severe: Anaphylaxis, severe skin reactions, and significant alterations in blood pressure.

Drug Interactions

-Anticoagulants: May enhance the effects of anticoagulants, leading to increased bleeding risk. -Other Anti-inflammatory Agents: May interact with other anti-inflammatory medications, potentially altering their effects. -Corticosteroids: The combined use with corticosteroids may require careful monitoring due to potential additive effects on inflammation.