VALGANCICLOVIR

Indications

For treatment for CMV retinitis in HIV patient, for prevention of CMV disease in patient with heart, kidney, or kidney-pancreas transplant.

Dosage

oral; 900mg once or twice a day

Contra-Indications

hypersensitivity reaction to valganciclovir, ganciclovir

Special Precautions

Paediatric: Safety and efficacy not established in congenital CMV Pregnancy: Category C Lactation: Safety not yet established Elderly: safety and efficacy above 65 years not yet established

Side Effects

:- (Severe) neutropenia, anaemia, Dyspnoea, Diarrhoea, Oral candidiasis, sepsis (bacteraemia, viraemia), cellulitis, urinary tract infection, Decreased appetite, anorexia, Depression, anxiety, confusion, abnormal thinking, Headache, insomnia, dysgeusia, (taste disturbance), Ear pain, Cough, Nausea, vomiting, abdominal pain, upper abdominal pain, dyspepsia, constipation, flatulence, dysphagia

Drug Interactions

Imipenem-cilastatin. Probenecid, Trimethoprim, Mycophenolate Mofetil, Stavudine, Zidovudine, Didanosine