Xanthinol Nicotinate

It enhances blood flow to the peripheral and cerebral tissues. Nutritive micro-circulation is enhanced by increasing the erythrocyte elasticity, improving the flow properties of the blood and reducing the peripheral resistance while simultaneously improving cardiac function. It improves cerebral metabolism and consequently cerebral function by increasing the glucose uptake across the blood-brain barrier and increase in glucose and oxygen utilisation in the brain cells. It also depresses raised serum lipid and fibrinogen levels and inhibits platelet aggregation.

Indications

Peripheral vascular disease. Disordered cerebral function. Hyperlipidaemia.

Dosage

300-600 mg 3 times daily with meals. Retard : 0.5g-1 g. 2 times daily with meals hyperlipidaemia : 1 gm 3 times daily.

Contra-Indications

Recent myocardial infarction, recent cerebro-vascular accident, acute haemorrhage, decompensated cardiac insufficiency.

Special Precautions

Combination with ganglion blocking & sympatholytic agents should be avoided. Patients with labile blood pressure or active peptic ulceration. Cardiac insufficiency, pulmonary oedema, oliguria and anuria. Paediatrics: Not recommended. Pregnancy: Contraindicated. Lactation: Contraindicated. Elderly: Caution should be taken.

Side Effects

Flushing (reddening of skin & sensation of heat).

Drug Interactions

Concomitant use of ganglion blockers and sympatholytic agents should be avoided.