A new study highlights a significant connection between lupus-related skin problems and an elevated risk of heart disease, specifically atherosclerotic heart disease, where arteries become clogged and lose flexibility. Published in JAMA Dermatology, the study found that people with cutaneous lupus are 72% more likely to develop heart disease compared to healthy individuals.

The research, led by Dr. Henry Chen, a dermatology resident at the University of Texas Southwestern Medical Center, underscores the need for enhanced cardiovascular screenings and referrals for lupus patients. "Lupus was associated with an increased risk for atherosclerotic cardiovascular disease, potentially warranting appropriate screening tests and clinician referrals," the study concluded.

Lupus, a chronic autoimmune disease, triggers inflammation that can damage the skin, joints, and internal organs. While systemic lupus erythematosus—the most common form of the disease—has long been linked to heightened heart disease risks, the study provides new insights into the cardiovascular implications of cutaneous lupus, a form that primarily affects the skin.

For the study, researchers analyzed data from more than 8,100 people with cutaneous lupus, nearly 25,000 with systemic lupus, over 192,500 with psoriasis, and nearly 81,400 healthy individuals. The data, sourced from insurance claims between 2018 and 2020, revealed that systemic lupus carries the highest cardiovascular risk, doubling the likelihood of heart disease compared to healthy controls. However, cutaneous lupus also presented a notable 72% increased risk.

These findings challenge the perception of cutaneous lupus as merely a skin disorder. Previous studies have linked it to conditions like metabolic syndrome and cancer, and this study adds cardiovascular disease to the list of associated risks.

The research team emphasized the importance of preventive care for patients with cutaneous lupus. “Clinicians caring for persons with cutaneous lupus can counsel patients regarding the importance of a heart-healthy lifestyle, including diet, exercise, and smoking avoidance,” the study noted.

Regular monitoring of blood pressure and cholesterol, along with prompt treatment when needed, was also recommended for this population. The study serves as a call to action for healthcare providers to address the broader health risks faced by individuals with lupus-related skin conditions, ensuring better long-term outcomes.