Lisinopril
Inhibition of ACE by lisinopril reduces the plasma angiotensin II levels which lead to vasodilation and reduction of aldosterone secretion thus lowering the blood pressure.All grades of hypertension, hypertension complicated by diabetes mellitus, gout, asthma & mental depression. Congestive cardiac failure.
Hypertension; Initially 10 mg once daily Maint. dose 20-40 mg/day. Max. 80 mg once daily. C.C.F.; Initially 2.5 mg once daily. Maint dose 5-20 mg once daily.
Hypersensitivity, aortic stenosis, outflow obstruction, angioedema related to previous treatment with ACE inhibitor, pregnancy, children, nursing mothers.
Renal impairment, lisinopril may cause hypotension in patients undergoing major surgery or during anaesthesia. In severe C.C.F. it may cause oliguria and/or progressive azotemia & rarely acute renal failure. Paediatrics: Contraindicated. Pregnancy: Contraindicated. Lactation: Drug passes into breast milk hence containdicated. Elderly: Reduced dose may be necessary.
Headache, dizziness, cough, hyper-kalaemia, diarrhoea, angioedema, hypotension.
Indomethacin may reduce hypotensive effect. Hydrochlorothiazide may potentiate antihypertensive effect. Raised serum lithium levels, hypotensive effect potentiated by alcohol. Inhibit tachycardia produced by vasodialators. Co-administration of cyclo-oxy-genase inhibitors cause reducton in renal function.
