Acebrophylline
Acebrophylline is a bronchodilator, primarily used to prevent and treat symptoms of asthma and chronic obstructive pulmonary disease (COPD). Acebrophylline works by relaxing muscles and opening the lungs' airways. It also functions as a mucolytic (cough/sputum thinner) drug, thinning and loosening phlegm (mucus) in the lungs, windpipe, and nose. As a result, it facilitates coughing and makes breathing easier by opening airways.Acute & Chronic bronchitis, bronchial asthma, sinusitis, dried rhinitis.
Adults: 100 mg twice daily for COPD and bronchial asthma. Acebrophylline syrup dose for children (50mg/5ml): -2.5 mL twice daily for children aged below 2 years. -2.5ml three times a day for children aged 2 to 5. -Above the age of 5, 5 ml twice daily, or as prescribed by a physician
Acebrophylline is contraindicated in: -Patients with Low blood pressure, heart attack, or irregular heart rhythms. -Allergy to xanthine derivatives and ambroxol. -Compromised liver or kidney functions.
Avoid excess dosage
CNS: Drowsiness, Headache Skin: Itching, Rashes Respiratory: Shortness or difficulty in breathing Gastro-intestinal: Appetite loss, oesophageal bleeding, vomiting, abdominal discomfort diarrhoea, constipation. Others: Raised white blood cell count, Changes in blood pressure, Fever with chills, numbness in arm.
-Acebrophylline plasma concentrations may be elevated when quinolones, cimetidine, erythromycin, oxytetracycline, lincomycin, and cephalexin are used concurrently. -The interaction of reserpine causes an increase in heart rate. Reserpine, on the other hand, is hardly used nowadays. -Barbiturates, such as phenytoin, may lower plasma concentrations and hence the efficacy of acebrophylline. -Concurrent use with frusemide promotes diuresis, causing the patient to pass urine more frequently. -Acebrophylline may exacerbate low blood potassium levels induced by medications such as steroids.
