Eprosartan Mesylate

Eprosartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the angiotensin I receptor in many tissues, such as vascular smooth muscle and the adrenal gland. Its action is therefore independent of the pathways for angiotensin II synthesis.

Indications

Hypertension.

Dosage

Adults : Initially, 600mg once daily, adjust according to response. Maintenance: 400-800 mg daily in 1 or 2 divided doses. Elderly:>75yr: initially, 300mg once daily. Renal clearance if (,60ml/min)-initially, 300mg once daily. Hepatic impairment: Mild to moderate hepatic impairment : initially, 300mg once daily.

Contra-Indications

Pregnancy (2nd and 3rd trimesters), hypersensitivity, sensitivity to other angiotensis II receptor antagonists, bilateral renal artery stenosis, primary hyperaldosteronism.

Special Precautions

Volume depletion, unilateral reanl artery stenosis, preexisting renal insufficiency significant aortic or mitral stenosis. Children, Lactation. Pregnancy - in first trimester use with caution (Category C) C/1 in 2nd and 3rd trimester.

Side Effects

Fatigue, depression, hypertriglyceridaemia, abdominal pain, flatulence, urinary tract infection, upper respiratory tract infection, rhinitis, pharyngitis, cough, viral infection, injury angina, asthma, arthritis, ataxia, increased BUN, Increased creatinine, eczema, oedema, esophagitis, gingivitis, gout, influenza-like symptoms, leg cramps, migraine, somnolence, tendonitis, tinnitus, tremor, urinary incontinence, leukopanenia, maculopapular rash neuritis, neutropaenia, paraesthesia, peripheral is

Drug Interactions

Inhibits CYP2C819, Increases risk of lithium toxicity. Increases risk of hyperlalaemia with potassium-sparing diuretics, potassium supplements or high doses of trimethorprim. Ephedra, yohimbe, ginseng may worsen hypertension.