Abacavir Sulphate with Lamivudine Zidovudine

Abacavir Sulphate with Lamivudine Zidovudine is a combination medication used in the management of human immunodeficiency virus (HIV) infection. It contains three active ingredients: Abacavir Sulphate, Lamivudine, and Zidovudine. Each component works synergistically to inhibit the replication of the HIV virus.

Indications

This medication is indicated for the treatment of HIV-1 infection in adults and pediatric patients weighing at least 25 kg. It is typically used in combination with other antiretroviral agents as part of a comprehensive HIV treatment regimen.

Dosage

The recommended dosage of Abacavir-Sulphate-with-Lamivudine-Zidovudine depends on various factors, including the patient's weight, renal function, and other medications being taken. It is crucial to follow the prescribed dosage and administration instructions provided by the healthcare provider.

Contra-Indications

-Hypersensitivity to any of the components in the medication. -Patients with a history of severe hepatic impairment.

Special Precautions

-Prior to initiation, screen for the HLA-B*5701 allele to prevent hypersensitivity reactions to Abacavir. -Monitor for signs of lactic acidosis, hepatomegaly, and exacerbations of hepatitis B in co-infected patients. -Assess renal function regularly, adjusting dosage in patients with impaired renal function.

Side Effects

Common side effects may include nausea, headache, fatigue, and gastrointestinal disturbances. Serious but rare side effects include hypersensitivity reactions (e.g., fever, rash, abdominal pain) and lactic acidosis.

Drug Interactions

Inform healthcare providers of all medications, including over-the-counter drugs and herbal supplements, to avoid potential interactions. Notable interactions may occur with drugs that affect renal function or those metabolized by similar pathways.