Severe recalcitrant psoriasis, cutaneous T-cell lymphoma, ichthyosiform erythroderma, keratosis, folliculosis, lamellar ichthyosis, linchen planus.
Adults : 0.5 to 0.75mg/kg/day orally.
Pancreatitis, disease of liver, renal disease, skeletal hyperostosis, premature epiphyseal colosure, hypertriglyceridemia, pregnancy, lactating mothers.
Liver enzyme and serum lipids must be checked periodically. Women of child-bearing age must wait at least 3 years for conception after completing acitretin treatment.
Most freequent side effects are alopecia, arthralgia, ceruminosis, cheilosis, dry eye and nose, eyeled dermatitis, gingivitis, headache, hypertonia, myalgia, nausea, polydipsia, pruritus of skin, rhinitis, skin photosensitivity, skin scaling of feet and hands spinal hyperostosis, stomatitis, vomiting.
Methotrexate, isotretinoin, tetracyclines, selected recinoids, vitamins-A, progestin (only contraceptives).