Adults: Oral: 0.5-1.5 gm in 2-3 divided doses. Parenteral: 2 ml I.M. 2-3 times daily. Children: Oral: 30-60 mg/kg/day. Parental(All four times/day by slow IV): 3-11 months: 0.1 ml, 1-4 years: 0.2 ml, 5-7 years: 0.4 ml, 8-11 years: 0.5 ml, 12-14 years: 0.8 ml.
Hepatic porphyria, infants less than 3 months or 5 kg wt. Hypersensitivity to pyra-zolone. Collapse states. G-6-PD deficiency.
Disorders of haematopoiesis. It interacts with alcohol & cyclo-sporin. Paediatrics: Contraindicated in children below the age of 3 months or weight 5 kg. Pregnancy: Unsafe. Lactation: Unsafe. Elderly: Use with caution.
Agranulocytosis, shock, fall in following rapid injection. Red colouration of urine. Analgesic intolerance on skin, mucus membranes, bronchial tract.
Cyclosporins level increases.