Antifungal agents are used to treat fungal infections by killing the fungal cells or inhibiting fungal growth. Antifungal drugs are classified into four major categories, azoles, polyenes, alkylamines, and echinocandins. Azoles and alkylamines attack cell membranes resulting in cell death. Echinocandins inhibit enzymes involved in cell wall formation, while polyenes make the cell wall porous, thus killing the fungal cells. They are commercially available in the form of injections, tablets, liquid preparations, and topical formulations like creams, ointments and sprays.
Fungal infections such as dandruff, jock itch, ringworm infection, fingernail infection, pneumonia, candidemia, pneumocystis, meningitis, vaginitis etc.
Hepatic impairment, kidney disorder.
Overuse of antifungal drugs may cause liver damage. Some antifungal drugs are contraindicated during pregnancy and breastfeeding therefore consult a healthcare professional before using it.
Allergic reactions, abdominal discomfort, dizziness, diarrhoea, weight loss, loss of appetite, vomiting, shortness of breath.
Antineoplastic drugs, antiretrovirals, and nephrotoxic drugs.
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