Armodafinil

Armodafinil is a wakefulness-promoting agent used primarily to treat excessive sleepiness. It is the R-enantiomer of modafinil and is believed to work by altering neurotransmitters in the brain. Armodafinil is known for its ability to improve wakefulness in patients with sleep disorders, making it a valuable medication for those suffering from narcolepsy, sleep apnea, and shift work sleep disorder. It is stimulant drug. Armodafinil is the R-enantiomer of modafinil which is a mixture of the R- and S-enantiomers.

Indications

Obstructive sleep apnea/hypoapnea syndrome, narcolepsy, and shift work sleep disorder.

Dosage

Oral; 150 or 250 mg every morning or 150mg daily one hour prior to the work shift.

Contra-Indications

Armodafinil is contraindicated in patients with: -Known hypersensitivity to armodafinil, modafinil, or any of the tablet's components. -History of left ventricular hypertrophy or mitral valve prolapse following previous administration of central nervous system stimulants.

Special Precautions

Paediatric: safety below 17 years not established Pregnancy: Category C; Use if risk to fetus outweighs benefits. Lactation : Excreted in milk; use with caution Elderly : use with caution

Side Effects

Headache, nervousness, insomnia, agitation, confusion, personality disorders, tremor, anxiety; GI disturbances; hypertension, palpitations, techycardia; angioedema; psychosis, depression, mania, abnormal LFTs. Stevens-johnson syndrome, erythema multiforme, Toxic epidermal necrolysis.

Drug Interactions

Armodafinil can interact with several medications, including: -Hormonal contraceptives: May reduce their effectiveness. -CYP3A4 substrates: Armodafinil can induce the metabolism of drugs like cyclosporine and midazolam. -CYP2C19 substrates: It can inhibit the metabolism of drugs such as omeprazole and diazepam.