ATENOLOL WITH INDAPAMIDE

-Atenolol is a beta-blocker that works by affecting the response to nerve impulses in certain parts of the body, primarily the heart. It reduces the heart rate and decreases the force of the heart's contractions, thereby lowering blood pressure. -Indapamide is a diuretic (water pill) that helps the kidneys eliminate excess water and salt from the body, reducing fluid retention and lowering blood pressure. -Atenolol is a potent beta blocker and an antihypertensive drug. -Indapamide belongs to a thiazide-like diuretics/ water pill class and is used to treat salt and fluid retention caused by heart failure.

Indications

-Hypertension (high blood pressure) where combination therapy is indicated. -Chest pain, arrhythmias, and fluid retention caused due to heart failure.

Dosage

-The dosage may vary based on individual patient characteristics and the severity of the condition. -Common starting doses may include Atenolol 50-100 mg and Indapamide 1.25 mg once daily. -Dosage adjustments should be made under the supervision of a healthcare professional.

Contra-Indications

-Hypersensitivity to Atenolol, Indapamide, or any component of the formulation. -Bradycardia (slow heart rate), heart block, cardiogenic shock, severe peripheral arterial circulatory disorders. -Lever disorders, renal impairment, hypokalaemia, chest pain, severe heart failure, diabetes, electrolyte imbalance, gout, asthma, and thyroid disorder.

Special Precautions

-Consult a Physician before using it during pregnancy and breastfeeding. Consuming alcohol while using atorvastatin and aspirin can cause chronic toxicity. It is not recommended for children below 18 years old. -Patients with impaired renal function. -Diabetes mellitus may be exacerbated; monitor blood glucose levels. -Do not abruptly discontinue; taper dosage under medical supervision. -Caution in patients with asthma or chronic obstructive pulmonary disease (COPD).

Side Effects

-Common side effects may include dizziness, fatigue, hypotension, electrolyte imbalance, and headache. -Rare but serious side effects include bradycardia, heart block, and allergic reactions. -Constipation, vision impairment, sweating, constipation, dehydration, muscle pain, nausea, vomiting, fatigue, and difficulty in breathing.

Drug Interactions

-Atenolol may interact with other antihypertensive agents, non-steroidal anti-inflammatory drugs (NSAIDs), and monoamine oxidase inhibitors (MAOIs). -Indapamide may interact with lithium, non-depolarizing muscle relaxants, and corticosteroids. -Diuretics ( hydrochlorothiazide), antihypertensive drugs ( chlorthalidone, ramipril), antidepressants ( lithium), vitamins (cholecalciferol), and heart-related drugs (amiodarone, digoxin).