Cefoperazone with Tazobactam

Cefoperazone with Tazobactam is a combination antibiotic medication that consists of cefoperazone, a third-generation cephalosporin, and tazobactam, a beta-lactamase inhibitor. This combination enhances the spectrum of activity against a wide range of bacteria.

Indications

-Complicated intra-abdominal infections -Complicated urinary tract infections -Lower respiratory tract infections -Skin and soft tissue infections -Gynecological infections -Septicemia -Bacterial meningitis

Dosage

Dosage may vary based on the specific infection, patient age, and renal function. It is crucial to follow the prescribed dosage and administration schedule provided by the healthcare professional.

Contra-Indications

Cefoperazone with Tazobactam is contraindicated in individuals with a known hypersensitivity to cephalosporins or beta-lactamase inhibitors.

Special Precautions

Patients with a history of penicillin allergy should be closely monitored. Renal impairment requires dosage adjustment. Caution in patients with a history of gastrointestinal diseases, especially colitis. Use with caution during pregnancy and lactation.

Side Effects

Common side effects may include diarrhea, nausea, vomiting, and allergic reactions. Serious side effects such as pseudomembranous colitis and anaphylaxis may occur, warranting immediate medical attention.

Drug Interactions

-Probenecid may increase cefoperazone levels. -Concurrent use with nephrotoxic drugs may increase the risk of renal toxicity.