Clarithromycin
It is a macrolide antibiotic with broad spectrum of activity.The mode of action is by binding to 50 S ribosomal unit and suppressing protein synthesis.URTI: pharyngitis and sinusitis, LRTI: bronchitis & pneumonia, skin & soft tissue infection.
Adults 250 mg twice daily for 5 - 14 days,can be increased to 500mg for severe infection.
Hypersensitivity, lactation and pregnancy.
First trimester of Pregnancy. Paediatrics: Safety in children less than 6 months not established. Pregnancy: Contraindicated. Lactation: Safety not established. Elderly: Dose adjustment need in patient with impaired renal function.
Nausea, vomitting, diarrhoea, abdominal pain, dyspepsia
Terfenadine results in cardiac arrhythmias. Increases the levels of theophylline and carbamazepine
